CJC-1295 (no DAC)
Also known as: Modified GRF 1-29 · Mod GRF(1-29) · CJC-1295 without DAC · GRF(1-29)
CJC-1295 no DAC binds and activates the GHRH receptor (GHRHR) on pituitary somatotroph cells, directly stimulating growth hormone synthesis and pulsatile release. The four amino acid substitutions prevent rapid degradation by dipeptidyl aminopeptidase IV (DPP-IV). Unlike the DAC version it...
What It Is
CJC-1295 no DAC binds and activates the GHRH receptor (GHRHR) on pituitary somatotroph cells, directly stimulating growth hormone synthesis and pulsatile release. The four amino acid substitutions prevent rapid degradation by dipeptidyl aminopeptidase IV (DPP-IV). Unlike the DAC version it does not bind albumin, maintaining a physiological half-life of 30-60 minutes. This preserves the natural pulsatile GH secretion pattern. Synergizes powerfully with GHS-R1a agonists (Ipamorelin, GHRP-2, GHRP-6).
Supplies Needed
Reconstitution solvent
Subcutaneous injection
Sterilization
Storage
Store at -20C for up to 2 years. Stable at 2-8C for up to 6 months.
Refrigerate at 2-8C; use within 30 days.
This information is provided for educational and research purposes only. Not approved for human consumption by the FDA or any regulatory body. Always consult a qualified medical professional.
Dosing Protocols
Timing: Before bed, fasted. Use alone or pair with 100 mcg Ipamorelin
↓ Apply these values to the reconstitution calculatorTiming: Morning fasted, post-workout, before bed - always fasted. Always combine with Ipamorelin at same injection for synergistic GH pulse
↓ Apply these values to the reconstitution calculatorTiming: Morning, midday, and bedtime. High-frequency dosing to maximize pulsatile GH release throughout the day
↓ Apply these values to the reconstitution calculatorWeekly Timeline
| Week | Expected Effects |
|---|---|
| Week 1 | Improved sleep depth; mild water retention; subtle energy improvement |
| Week 2 | Better recovery; improved skin hydration |
| Week 4 | Noticeable body composition changes; improved muscle fullness |
| Week 8 | Significant body composition improvements; enhanced collagen; better sleep architecture |
| Week 12 | Full GH optimization benefits; sustained lean mass and fat loss improvements |
Reconstitution Calculator
1 unit on U-100 syringe = 0.01 mL · Always label your vial after reconstitution
Injection Technique & Reconstitution
- Remove flip-top cap from the vial
- Swab rubber stopper with alcohol swab and allow to dry for 30 seconds
- Draw 2 mL bacteriostatic water into syringe
- Inject BAC water slowly down the side wall of the vial
- Gently swirl until dissolved - do not shake
- Label with date; refrigerate at 2-8C
Use our free reconstitution calculator to get the exact syringe units for your vial size and dose.
Mechanism of Action
CJC-1295 no DAC binds and activates the GHRH receptor (GHRHR) on pituitary somatotroph cells, directly stimulating growth hormone synthesis and pulsatile release. The four amino acid substitutions prevent rapid degradation by dipeptidyl aminopeptidase IV (DPP-IV). Unlike the DAC version it does not bind albumin, maintaining a physiological half-life of 30-60 minutes. This preserves the natural pulsatile GH secretion pattern. Synergizes powerfully with GHS-R1a agonists (Ipamorelin, GHRP-2, GHRP-6).
Key Research Papers
Demonstrated the complementary receptor systems for GHRH analogs and GHS peptides in stimulating GH release.
View on PubMed →Stacks Well With
The classic GH optimization stack. CJC-1295 no DAC activates GHRH receptors while Ipamorelin activates GHS-R1a - dual-receptor activation produces 2-10x greater GH pulse than either alone.
More potent alternative to Ipamorelin stacking - produces very large GH pulses but with some cortisol elevation. Used by those prioritizing maximum GH output.
Frequently Asked Questions
Without DAC, CJC-1295 has a 30-minute to 2-hour half-life and causes natural pulsatile GH release. With DAC, albumin binding extends the half-life to ~8 days, causing sustained GH elevation.
It is strongly recommended. CJC-1295 and Ipamorelin work via different receptors and produce synergistic GH release that is significantly greater than either peptide alone.
Legal Status by Region
This information is provided for educational and research purposes only. Not approved for human consumption by the FDA or any regulatory body. Always consult a qualified medical professional.