Dihexa
Also known as: PNB-0408 · N-hexanoic-Tyr-Ile-(6) aminohexanoic amide
Dihexa potentiates HGF (hepatocyte growth factor) signaling by binding with high affinity to HGF and facilitating its interaction with the c-Met receptor. This leads to BDNF-like synaptogenic effects, promotes dendritic spine formation, enhances long-term potentiation (LTP), and increases synaptic density...
What It Is
Dihexa potentiates HGF (hepatocyte growth factor) signaling by binding with high affinity to HGF and facilitating its interaction with the c-Met receptor. This leads to BDNF-like synaptogenic effects, promotes dendritic spine formation, enhances long-term potentiation (LTP), and increases synaptic density in the hippocampus. It crosses the blood-brain barrier readily due to its lipophilic structure. Estimated to be 7 orders of magnitude more potent than BDNF at promoting new synapse formation.
Supplies Needed
Reconstitution
Subcutaneous injection of small volumes
Intranasal delivery
Storage
Store at -20°C; stable 2+ years
Refrigerate at 2–8°C; use within 30 days
This information is provided for educational and research purposes only. Not approved for human consumption by the FDA or any regulatory body. Always consult a qualified medical professional.
Dosing Protocols
Timing: Morning. Start very low u2014 potency is extremely high. Intranasal: dissolve in saline for nasal delivery.
↓ Apply these values to the reconstitution calculatorTiming: Morning. Allow off-days to avoid tolerance. Effects can be long-lasting after cycles.
↓ Apply these values to the reconstitution calculatorTiming: Morning. Very advanced use only. Monitor for over-stimulation or anxiety. Stack with Semax or Selank for anxiety buffer.
↓ Apply these values to the reconstitution calculatorWeekly Timeline
| Week | Expected Effects |
|---|---|
| Week 1 | Increased mental clarity and processing speed; some users notice improved word recall |
| Week 2 | Enhanced working memory; improved learning retention; possible vivid dreams |
| Week 4 | Noticeable synaptogenic effects u2014 significantly improved memory consolidation and retrieval |
| Week 8 | Full cognitive enhancement; effects may persist after cycle ends due to lasting structural changes |
Reconstitution Calculator
1 unit on U-100 syringe = 0.01 mL · Always label your vial after reconstitution
Injection Technique & Reconstitution
- Remove cap from vial and wipe stopper with alcohol swab
- Draw 2 mL bacteriostatic water into syringe
- Insert needle at angle; inject BAC water slowly down the vial wall
- Gently swirl until fully dissolved u2014 do not shake
- Store reconstituted vial at 2u20138u00b0C
Use our free dosing calculator to get the exact syringe units for your vial size and dose.
Mechanism of Action
Dihexa potentiates HGF (hepatocyte growth factor) signaling by binding with high affinity to HGF and facilitating its interaction with the c-Met receptor. This leads to BDNF-like synaptogenic effects, promotes dendritic spine formation, enhances long-term potentiation (LTP), and increases synaptic density in the hippocampus. It crosses the blood-brain barrier readily due to its lipophilic structure. Estimated to be 7 orders of magnitude more potent than BDNF at promoting new synapse formation.
Key Research Papers
Demonstrated neuroprotective effects of HGF-potentiating compounds in Huntington's disease mouse models.
View on PubMed →Showed Dihexa dramatically enhanced spatial memory and learning in aged rats, reversing age-related cognitive decline.
View on PubMed →Frequently Asked Questions
Dihexa is estimated to be approximately 10 million times (7 orders of magnitude) more potent than BDNF at promoting synaptogenesis in preclinical models, which is why doses are extremely low.
Animal studies show remarkable reversal of cognitive impairment. Human clinical data is extremely limited. It is not approved for any medical use.
Some users report cognitive effects within days; full synaptogenic effects likely develop over weeks of consistent use.
Legal Status by Region
This information is provided for educational and research purposes only. Not approved for human consumption by the FDA or any regulatory body. Always consult a qualified medical professional.