KPV
Also known as: Lys-Pro-Val · alpha-MSH fragment · KPV tripeptide
KPV binds to melanocortin receptor 1 (MC1R) on immune cells and enterocytes, activating anti-inflammatory signaling cascades including cAMP/PKA. It inhibits NF-kB activation, reducing production of pro-inflammatory cytokines (TNF-alpha, IL-6, IL-1beta). It modulates macrophage polarization toward the anti-inflammatory M2 phenotype. In...
What It Is
KPV binds to melanocortin receptor 1 (MC1R) on immune cells and enterocytes, activating anti-inflammatory signaling cascades including cAMP/PKA. It inhibits NF-kB activation, reducing production of pro-inflammatory cytokines (TNF-alpha, IL-6, IL-1beta). It modulates macrophage polarization toward the anti-inflammatory M2 phenotype. In the gut, KPV specifically reduces intestinal inflammation, protects the gut epithelial barrier, and decreases inflammatory cytokine production in the colon. It can penetrate into intestinal epithelial cells to directly inhibit inflammatory pathways from within.
Supplies Needed
Reconstitution solvent
Subcutaneous injection
Sterilization
Storage
Store at -20C for up to 2 years.
Refrigerate at 2-8C; use within 30 days.
This information is provided for educational and research purposes only. Not approved for human consumption by the FDA or any regulatory body. Always consult a qualified medical professional.
Dosing Protocols
Timing: With meals for GI conditions; fasted for systemic use. Oral is preferred for IBD/Crohn's as peptide acts locally in gut
↓ Apply these values to the reconstitution calculatorTiming: With or before meals for gut; any time for subcutaneous. Oral for GI; subcutaneous for systemic joint/skin inflammation
↓ Apply these values to the reconstitution calculatorTiming: With meals. Higher doses for severe IBD flares; consider stacking with BPC-157 for synergistic gut healing
↓ Apply these values to the reconstitution calculatorWeekly Timeline
| Week | Expected Effects |
|---|---|
| Week 1 | Reduced gut inflammation and discomfort; improved bowel regularity |
| Week 2 | Continued reduction in IBD symptoms; improved gut barrier function |
| Week 4 | Significant improvement in IBD flare symptoms; reduced need for other anti-inflammatory medications |
| Week 8 | Sustained remission of gut inflammation; improved gut microbiome environment |
Reconstitution Calculator
1 unit on U-100 syringe = 0.01 mL · Always label your vial after reconstitution
Injection Technique & Reconstitution
- Remove flip-top cap from the vial
- Swab rubber stopper with alcohol swab
- Draw 2 mL bacteriostatic water into syringe
- Inject slowly down the vial wall
- Gently swirl until dissolved
- Label with date; refrigerate at 2-8C
- For oral use: dissolve appropriate dose in small amount of water and drink
Use our free calculate your KPV dose to get the exact syringe units for your vial size and dose.
Mechanism of Action
KPV binds to melanocortin receptor 1 (MC1R) on immune cells and enterocytes, activating anti-inflammatory signaling cascades including cAMP/PKA. It inhibits NF-kB activation, reducing production of pro-inflammatory cytokines (TNF-alpha, IL-6, IL-1beta). It modulates macrophage polarization toward the anti-inflammatory M2 phenotype. In the gut, KPV specifically reduces intestinal inflammation, protects the gut epithelial barrier, and decreases inflammatory cytokine production in the colon. It can penetrate into intestinal epithelial cells to directly inhibit inflammatory pathways from within.
Key Research Papers
Demonstrated significant reduction in intestinal inflammation and improved colonic epithelial barrier integrity in mouse colitis models treated with KPV.
View on PubMed →Stacks Well With
Synergistic gut healing - KPV provides anti-inflammatory NF-kB inhibition while BPC-157 promotes tissue repair and mucosal healing. Highly effective combination for IBD and leaky gut.
Comprehensive gut immune modulation - KPV reduces inflammation while LL-37 provides antimicrobial protection and immune regulation.
Frequently Asked Questions
KPV is a potent anti-inflammatory peptide used primarily for inflammatory bowel disease (IBD), Crohn's disease, ulcerative colitis, and leaky gut. It also has systemic anti-inflammatory properties for joint and skin conditions.
Yes - oral KPV is effective for gut conditions because it acts locally in the intestinal tract. For systemic anti-inflammatory effects, subcutaneous injection achieves higher bioavailability.
KPV and BPC-157 work via different mechanisms and are highly complementary. KPV specifically targets NF-kB inflammatory pathways. BPC-157 promotes tissue repair and mucosal regeneration. Stacking both provides comprehensive gut healing.
Legal Status by Region
This information is provided for educational and research purposes only. Not approved for human consumption by the FDA or any regulatory body. Always consult a qualified medical professional.