CJC-1295 (with DAC)
Also known as: CJC-1295 DAC · DAC:GRF · CJC1295
CJC-1295 with DAC contains a maleimidoproprionic acid (MPA) group attached to a lysine residue, which forms a covalent thioether bond with the cysteine-34 residue of serum albumin in vivo. This albumin binding extends the half-life to approximately 6-8 days. The...
What It Is
CJC-1295 with DAC contains a maleimidoproprionic acid (MPA) group attached to a lysine residue, which forms a covalent thioether bond with the cysteine-34 residue of serum albumin in vivo. This albumin binding extends the half-life to approximately 6-8 days. The GHRH analog portion continuously stimulates GHRH receptors on pituitary somatotrophs, causing sustained GH and IGF-1 elevation rather than pulsatile release. This provides convenient once-weekly dosing.
Supplies Needed
Reconstitution solvent
Injection of larger doses
Sterilization
Storage
Store at -20C for up to 2 years. Stable at 2-8C for several months.
Refrigerate at 2-8C; use within 30 days.
This information is provided for educational and research purposes only. Not approved for human consumption by the FDA or any regulatory body. Always consult a qualified medical professional.
Dosing Protocols
Timing: Any time of day - inject once per week. Simple weekly dosing; can combine with daily Ipamorelin for enhanced GH pulse synergy
↓ Apply these values to the reconstitution calculatorTiming: Weekly; same day each week. 2 mg weekly is the most studied dose; can be stacked with daily Ipamorelin
↓ Apply these values to the reconstitution calculatorTiming: Consistent schedule. Higher doses for significant GH/IGF-1 elevation; monitor water retention and blood glucose
↓ Apply these values to the reconstitution calculatorWeekly Timeline
| Week | Expected Effects |
|---|---|
| Week 1 | GH and IGF-1 levels begin rising; mild water retention; improved sleep |
| Week 2 | Sustained IGF-1 elevation; improved recovery; early body composition changes |
| Week 4 | Noticeable lean mass improvement; reduction in body fat |
| Week 8 | Significant body composition changes; improved skin quality; sustained energy |
Reconstitution Calculator
1 unit on U-100 syringe = 0.01 mL · Always label your vial after reconstitution
Injection Technique & Reconstitution
- Remove flip-top cap from the vial
- Swab rubber stopper with alcohol swab and allow to dry
- Draw 2 mL bacteriostatic water into syringe
- Slowly inject BAC water down the side of the vial
- Gently swirl until dissolved - do not shake
- Label with reconstitution date; refrigerate at 2-8C
Use our free peptide dosage calculator to get the exact syringe units for your vial size and dose.
Mechanism of Action
CJC-1295 with DAC contains a maleimidoproprionic acid (MPA) group attached to a lysine residue, which forms a covalent thioether bond with the cysteine-34 residue of serum albumin in vivo. This albumin binding extends the half-life to approximately 6-8 days. The GHRH analog portion continuously stimulates GHRH receptors on pituitary somatotrophs, causing sustained GH and IGF-1 elevation rather than pulsatile release. This provides convenient once-weekly dosing.
Key Research Papers
Clinical study showing CJC-1295 with DAC produced sustained GH and IGF-1 elevation for up to 6 days after single injection in healthy adults.
View on PubMed →Stacks Well With
While DAC version provides sustained GHRH stimulation, adding daily Ipamorelin adds GHS-R1a activation for additional GH pulse augmentation on top of baseline elevation.
Combine systemic GH elevation from CJC-1295 DAC with BPC-157's local tissue repair for comprehensive recovery enhancement.
Frequently Asked Questions
Once weekly is the standard protocol due to the ~8-day half-life. Some protocols use once every 2 weeks at higher doses.
It depends on goals. With DAC offers convenience (once-weekly) and sustained IGF-1 elevation. Without DAC preserves physiological pulsatile GH release. Many researchers prefer no DAC for more natural GH patterns.
Legal Status by Region
This information is provided for educational and research purposes only. Not approved for human consumption by the FDA or any regulatory body. Always consult a qualified medical professional.