Epithalon
Also known as: Epitalon · Epithalone · Epithalamin synthetic · AEDG tetrapeptide
Epithalon activates telomerase enzyme (hTERT), which elongates telomeres and extends cellular replicative lifespan. It regulates melatonin production by stimulating the pineal gland, normalizing circadian rhythm. Epithalon modulates gene expression by opening chromatin and activating repressed genes, particularly in aging cells....
What It Is
Epithalon activates telomerase enzyme (hTERT), which elongates telomeres and extends cellular replicative lifespan. It regulates melatonin production by stimulating the pineal gland, normalizing circadian rhythm. Epithalon modulates gene expression by opening chromatin and activating repressed genes, particularly in aging cells. It reduces oxidative stress by upregulating antioxidant enzymes (superoxide dismutase, catalase). It also modulates cortisol and gonadotropin levels, exhibiting anti-aging and anti-cancer properties in animal studies.
Supplies Needed
Reconstitution solvent
Subcutaneous injection
Sterilization
Storage
Store at -20C for up to 2 years. Very stable peptide due to small size.
Refrigerate at 2-8C; use within 30 days.
This information is provided for educational and research purposes only. Not approved for human consumption by the FDA or any regulatory body. Always consult a qualified medical professional.
Dosing Protocols
Timing: Evening, before bed. Classic 10-day course protocol used in Russian longevity research; repeat every 6 months
↓ Apply these values to the reconstitution calculatorTiming: Evening. Higher dose 20-day course for more pronounced anti-aging effects
↓ Apply these values to the reconstitution calculatorTiming: Evening. Maximum studied doses in Russian clinical trials; 3-4 courses per year
↓ Apply these values to the reconstitution calculatorWeekly Timeline
| Week | Expected Effects |
|---|---|
| Week 1 | Improved sleep quality and vivid dreams; mild sense of wellbeing |
| Week 2 | Improved hormonal balance; enhanced energy levels; better sleep architecture |
| Week 4 | Cumulative anti-aging benefits building; improved skin quality noted by some users |
| Week 26 | After multiple courses: improved telomere biomarkers; sustained sleep improvement; anti-aging benefits accumulate over repeated cycles |
Reconstitution Calculator
1 unit on U-100 syringe = 0.01 mL · Always label your vial after reconstitution
Injection Technique & Reconstitution
- Remove flip-top cap from the vial
- Swab rubber stopper with alcohol swab
- Draw 2 mL bacteriostatic water into syringe
- Inject slowly down the vial wall
- Gently swirl until dissolved
- Label with reconstitution date; refrigerate at 2-8C
Use our free mixing calculator to get the exact syringe units for your vial size and dose.
Mechanism of Action
Epithalon activates telomerase enzyme (hTERT), which elongates telomeres and extends cellular replicative lifespan. It regulates melatonin production by stimulating the pineal gland, normalizing circadian rhythm. Epithalon modulates gene expression by opening chromatin and activating repressed genes, particularly in aging cells. It reduces oxidative stress by upregulating antioxidant enzymes (superoxide dismutase, catalase). It also modulates cortisol and gonadotropin levels, exhibiting anti-aging and anti-cancer properties in animal studies.
Key Research Papers
Demonstrated that Epithalon activated telomerase in human somatic cells and resulted in telomere elongation - a key mechanism for cellular anti-aging effects.
View on PubMed →Showed that Epithalamin treatment increased mean lifespan in aging mice and reduced incidence of spontaneous carcinogenesis.
View on PubMed →Stacks Well With
Anti-aging synergy - Epithalon addresses telomere length and cellular aging while GHK-Cu promotes tissue repair, collagen synthesis, and stem cell activation.
Comprehensive longevity stack - Epithalon extends cellular lifespan while Thymosin Alpha-1 optimizes immune function for healthy aging.
Frequently Asked Questions
Epithalon is used primarily as an anti-aging peptide. It activates telomerase to elongate telomeres, regulates melatonin production for sleep, and has antioxidant and epigenetic effects that may extend healthspan.
Animal and cell culture studies show Epithalon activates telomerase and results in measurable telomere elongation. Human studies are limited but the mechanism is plausible. Russian clinical research shows improved longevity markers in elderly subjects.
Traditional Russian protocol uses 10-20 consecutive days of daily injections, repeated 2-4 times per year (every 3-6 months). This cycled approach is based on decades of Russian gerontology research.
Legal Status by Region
This information is provided for educational and research purposes only. Not approved for human consumption by the FDA or any regulatory body. Always consult a qualified medical professional.