GHRP-2
Also known as: Growth Hormone Releasing Peptide 2 · KP-102 · Pralmorelin
GHRP-2 is a potent agonist of the ghrelin receptor (GHS-R1a), stimulating GH release from pituitary somatotrophs. It is more potent than GHRP-6 for GH release but, unlike Ipamorelin, it also significantly elevates cortisol, ACTH, and prolactin via off-target melanocortin receptor...
What It Is
GHRP-2 is a potent agonist of the ghrelin receptor (GHS-R1a), stimulating GH release from pituitary somatotrophs. It is more potent than GHRP-6 for GH release but, unlike Ipamorelin, it also significantly elevates cortisol, ACTH, and prolactin via off-target melanocortin receptor effects. It acts synergistically with GHRH analogs (CJC-1295, Sermorelin) to amplify GH pulses. GHRP-2 used to be the diagnostic standard for growth hormone deficiency testing in some countries (Pralmorelin injection test). It also has some appetite-stimulating effects but less than GHRP-6.
Supplies Needed
Reconstitution solvent
Subcutaneous injection
Sterilization
Storage
Store at -20C for up to 2 years.
Refrigerate at 2-8C; use within 30 days.
This information is provided for educational and research purposes only. Not approved for human consumption by the FDA or any regulatory body. Always consult a qualified medical professional.
Dosing Protocols
Timing: Before bed or morning fasted. Less preferred than Ipamorelin due to cortisol elevation; suitable for short cycles
↓ Apply these values to the reconstitution calculatorTiming: Morning fasted, post-workout, before bed. Always combine with CJC-1295 for synergistic GH release; cortisol elevation limits long-term use
↓ Apply these values to the reconstitution calculatorTiming: Morning, midday, bedtime - all fasted. Maximum GH stimulation when paired with CJC-1295; cycling mandatory to prevent cortisol issues
↓ Apply these values to the reconstitution calculatorWeekly Timeline
| Week | Expected Effects |
|---|---|
| Week 1 | Increased GH pulses; improved sleep depth; water retention; appetite increase |
| Week 2 | Improved recovery; early body composition changes; cortisol elevation evident |
| Week 4 | Significant GH-mediated body composition improvement; monitor cortisol |
| Week 8 | Maximum GH optimization benefits; cycling recommended at this point |
Reconstitution Calculator
1 unit on U-100 syringe = 0.01 mL · Always label your vial after reconstitution
Injection Technique & Reconstitution
- Remove flip-top cap from the vial
- Swab rubber stopper with alcohol swab
- Draw 2 mL bacteriostatic water into syringe
- Inject slowly down the vial wall
- Gently swirl until dissolved
- Label with date; refrigerate at 2-8C
Use our free peptide dosage calculator to get the exact syringe units for your vial size and dose.
Mechanism of Action
GHRP-2 is a potent agonist of the ghrelin receptor (GHS-R1a), stimulating GH release from pituitary somatotrophs. It is more potent than GHRP-6 for GH release but, unlike Ipamorelin, it also significantly elevates cortisol, ACTH, and prolactin via off-target melanocortin receptor effects. It acts synergistically with GHRH analogs (CJC-1295, Sermorelin) to amplify GH pulses. GHRP-2 used to be the diagnostic standard for growth hormone deficiency testing in some countries (Pralmorelin injection test). It also has some appetite-stimulating effects but less than GHRP-6.
Key Research Papers
Comparative study showing GHRP-2 potency for GH release and its non-selective effects on cortisol and ACTH vs more selective Ipamorelin.
View on PubMed →Stacks Well With
GHRH + GHS-R1a dual activation produces dramatically amplified GH pulses - the most potent GH stimulation achievable with peptides. GHRP-2 + CJC-1295 stack is used when maximum GH output is the goal.
If Ipamorelin is tolerated, it is generally preferred over GHRP-2 for long-term use due to selectivity. GHRP-2 can be used for short-cycle maximum GH stimulation.
Frequently Asked Questions
GHRP-2 produces more GH per dose but significantly elevates cortisol, ACTH, and prolactin. Ipamorelin is highly selective and does not raise these hormones. For long-term use, Ipamorelin is preferred. GHRP-2 is used for maximum short-term GH output.
Yes - this produces the highest GH pulse achievable with peptides. CJC-1295 activates GHRH receptors and GHRP-2 activates GHS-R1a simultaneously, producing synergistic GH release far beyond either alone.
Legal Status by Region
This information is provided for educational and research purposes only. Not approved for human consumption by the FDA or any regulatory body. Always consult a qualified medical professional.