Gonadorelin
Also known as: GnRH · Gonadotropin-releasing hormone · Luteinizing hormone-releasing hormone · LHRH · Factrel
Gonadorelin binds to GnRH receptors (GnRHR) on pituitary gonadotroph cells, stimulating the release of both luteinizing hormone (LH) and follicle-stimulating hormone (FSH). In males, LH stimulates Leydig cells in the testes to produce testosterone; FSH stimulates Sertoli cells for sperm...
What It Is
Gonadorelin binds to GnRH receptors (GnRHR) on pituitary gonadotroph cells, stimulating the release of both luteinizing hormone (LH) and follicle-stimulating hormone (FSH). In males, LH stimulates Leydig cells in the testes to produce testosterone; FSH stimulates Sertoli cells for sperm production. In females, it triggers the LH surge for ovulation. Pulsatile dosing is critical — continuous administration desensitizes GnRH receptors and suppresses LH/FSH (the mechanism of GnRH agonist contraceptives). Pulsatile dosing (every 90-120 minutes or 2x daily mimics this) maintains or restores testicular/ovarian function.
Supplies Needed
Reconstitution
Small volume subcutaneous injection
Sterilization
Storage
Store at 2–8°C or -20°C; avoid heat
Refrigerate at 2–8°C; use within 30 days
This information is provided for educational and research purposes only. Not approved for human consumption by the FDA or any regulatory body. Always consult a qualified medical professional.
Dosing Protocols
Timing: Morning and evening. Pulsatile dosing protocol. Do not dose more frequently than twice daily at this level u2014 mimics natural GnRH pulses.
↓ Apply these values to the reconstitution calculatorTiming: Morning and evening. Most common TRT-support protocol. Prevents testicular atrophy and maintains fertility during testosterone therapy.
↓ Apply these values to the reconstitution calculatorTiming: Per protocol. Pump delivery (every 90 minutes) most closely mimics physiologic pulsatile GnRH u2014 used in hypogonadotropic hypogonadism treatment.
↓ Apply these values to the reconstitution calculatorWeekly Timeline
| Week | Expected Effects |
|---|---|
| Week 1 | Increased LH and FSH within hours of first dose; testicular stimulation begins; reduced testicular atrophy |
| Week 2 | Testosterone levels begin rising if HPG axis is intact; improved libido |
| Week 4 | Maintained testicular volume; normalized LH/FSH; testosterone approaching baseline |
| Week 8 | Full HPG axis restoration; maintained fertility markers; stable testosterone levels |
Reconstitution Calculator
1 unit on U-100 syringe = 0.01 mL · Always label your vial after reconstitution
Injection Technique & Reconstitution
- Wipe vial stopper with alcohol swab
- Draw 2 mL bacteriostatic water into syringe
- Inject BAC water slowly along vial wall
- Gently swirl until fully dissolved
- Refrigerate at 2u20138u00b0C; use within 30 days
Use our free peptide calculator to get the exact syringe units for your vial size and dose.
Mechanism of Action
Gonadorelin binds to GnRH receptors (GnRHR) on pituitary gonadotroph cells, stimulating the release of both luteinizing hormone (LH) and follicle-stimulating hormone (FSH). In males, LH stimulates Leydig cells in the testes to produce testosterone; FSH stimulates Sertoli cells for sperm production. In females, it triggers the LH surge for ovulation. Pulsatile dosing is critical — continuous administration desensitizes GnRH receptors and suppresses LH/FSH (the mechanism of GnRH agonist contraceptives). Pulsatile dosing (every 90-120 minutes or 2x daily mimics this) maintains or restores testicular/ovarian function.
Key Research Papers
Characterized GnRH receptor structure and signaling mechanism, foundational for understanding Gonadorelin pharmacology.
View on PubMed →Demonstrated that pulsatile Gonadorelin delivery successfully restored normal LH secretion and testosterone levels in men with hypothalamic hypogonadism.
View on PubMed →Stacks Well With
Kisspeptin stimulates GnRH release upstream in the hypothalamus; Gonadorelin acts at the pituitary. Together they provide full HPG axis stimulation from hypothalamus to gonads.
Sermorelin stimulates GH axis; Gonadorelin stimulates HPG axis u2014 used together for comprehensive hormonal optimization without exogenous hormones
Frequently Asked Questions
Gonadorelin stimulates the pituitary to release LH and FSH naturally, preserving the full HPG axis. hCG acts directly on Leydig cells like LH but doesn't stimulate FSH (so doesn't support sperm production as effectively). Gonadorelin is also less likely to cause antibody formation.
Continuous GnRH exposure causes downregulation and desensitization of GnRH receptors, paradoxically suppressing LH/FSH. This is how GnRH agonists like Lupron suppress testosterone in prostate cancer. Pulsatile dosing mimics the natural 90-120 minute pulse intervals.
Yes u2014 used as PCT (post-cycle therapy), pulsatile Gonadorelin can help restart the HPG axis. It is often combined with SERMs like Clomid/Nolvadex for full recovery.
Legal Status by Region
This information is provided for educational and research purposes only. Not approved for human consumption by the FDA or any regulatory body. Always consult a qualified medical professional.