Hexarelin
Also known as: Examorelin · EP-23905 · MF-6003 · His-D-2MeTrp-Ala-Trp-D-Phe-Lys hexapeptide
Hexarelin is the most potent GHS-R1a agonist of the first-generation GHRPs, producing the highest GH release per dose. It also binds the CD36 scavenger receptor (now called the hexarelin receptor) independently of GH release, producing direct cardioprotective effects including reduced...
What It Is
Hexarelin is the most potent GHS-R1a agonist of the first-generation GHRPs, producing the highest GH release per dose. It also binds the CD36 scavenger receptor (now called the hexarelin receptor) independently of GH release, producing direct cardioprotective effects including reduced cardiac fibrosis, improved ejection fraction, and protection from ischemic injury. Like GHRP-2, it raises cortisol and ACTH. Hexarelin desensitizes more rapidly than other GHRPs with continuous use, necessitating cycling. It activates PI3K/Akt survival signaling in cardiomyocytes directly via CD36.
Supplies Needed
Reconstitution solvent
Subcutaneous injection
Sterilization
Storage
Store at -20C for up to 2 years.
Refrigerate at 2-8C; use within 30 days.
This information is provided for educational and research purposes only. Not approved for human consumption by the FDA or any regulatory body. Always consult a qualified medical professional.
Dosing Protocols
Timing: Before bed or post-workout. Strict cycling required (4-6 weeks on, 4 weeks off) due to rapid desensitization; more potent than GHRP-2 per mcg
↓ Apply these values to the reconstitution calculatorTiming: Morning fasted and before bed. Combine with CJC-1295 for maximum effect; must cycle off to prevent desensitization
↓ Apply these values to the reconstitution calculatorTiming: Morning, post-workout, bedtime. Maximum potency GH secretagogue; desensitization still occurs; cardioprotective benefits occur even at low doses via CD36
↓ Apply these values to the reconstitution calculatorWeekly Timeline
| Week | Expected Effects |
|---|---|
| Week 1 | Very strong GH pulses; significant water retention; cortisol elevation |
| Week 2 | Early GH-driven body composition changes; improved recovery; early desensitization warning |
| Week 4 | Peak GH stimulation effect before desensitization becomes significant; strong body composition improvement |
| Week 6 | Cycle off to allow receptor recovery; cardioprotective benefits from CD36 continue with lower doses |
Reconstitution Calculator
1 unit on U-100 syringe = 0.01 mL · Always label your vial after reconstitution
Injection Technique & Reconstitution
- Remove flip-top cap from the vial
- Swab rubber stopper with alcohol swab
- Draw 2 mL bacteriostatic water into syringe
- Inject slowly down the vial wall
- Gently swirl until dissolved
- Label with date; refrigerate at 2-8C
Use our free reconstitution calculator to get the exact syringe units for your vial size and dose.
Mechanism of Action
Hexarelin is the most potent GHS-R1a agonist of the first-generation GHRPs, producing the highest GH release per dose. It also binds the CD36 scavenger receptor (now called the hexarelin receptor) independently of GH release, producing direct cardioprotective effects including reduced cardiac fibrosis, improved ejection fraction, and protection from ischemic injury. Like GHRP-2, it raises cortisol and ACTH. Hexarelin desensitizes more rapidly than other GHRPs with continuous use, necessitating cycling. It activates PI3K/Akt survival signaling in cardiomyocytes directly via CD36.
Key Research Papers
Demonstrated Hexarelin's direct cardioprotective effects through CD36 receptor, independent of GH release, including reduced myocardial fibrosis and improved cardiac function.
View on PubMed →Stacks Well With
The most potent GHRP paired with GHRH analog produces maximum GH pulses. For short-cycle maximum GH output this is the strongest combination.
Hexarelin's cardioprotective effects combined with BPC-157's vascular and tissue repair effects provide comprehensive cardiovascular protection.
Frequently Asked Questions
Yes - Hexarelin is the most potent GHS-R1a agonist of the first-generation GHRPs, producing the highest GH release per microgram. However, it also desensitizes faster than others, requiring strict cycling.
Hexarelin has a unique direct cardioprotective mechanism via CD36 receptor binding that is independent of GH release. This makes it useful for cardiac protection and recovery even in cases where GH stimulation is not the primary goal.
Legal Status by Region
This information is provided for educational and research purposes only. Not approved for human consumption by the FDA or any regulatory body. Always consult a qualified medical professional.