Ipamorelin
Also known as: NNC 26-0161 · Ipamorelin acetate
Ipamorelin selectively binds the ghrelin receptor (GHS-R1a) in the pituitary and hypothalamus, stimulating pulsatile growth hormone release from somatotroph cells. It mimics ghrelin's GH-releasing action without significantly elevating cortisol, ACTH, prolactin, or aldosterone - making it the most selective GHRP...
What It Is
Ipamorelin selectively binds the ghrelin receptor (GHS-R1a) in the pituitary and hypothalamus, stimulating pulsatile growth hormone release from somatotroph cells. It mimics ghrelin's GH-releasing action without significantly elevating cortisol, ACTH, prolactin, or aldosterone - making it the most selective GHRP available. It does not cause significant appetite stimulation unlike GHRP-6. Combined with CJC-1295 to amplify GH pulses via dual GHRH and GHS-R activation.
Supplies Needed
Reconstitution solvent
Subcutaneous injection
Sterilization
Storage
Store at -20C for up to 2 years. Stable at 2-8C for several months. Protect from light.
Refrigerate at 2-8C; use within 30 days.
This information is provided for educational and research purposes only. Not approved for human consumption by the FDA or any regulatory body. Always consult a qualified medical professional.
Dosing Protocols
Timing: Before bed, fasted (2 hours after last meal). Bedtime injection capitalizes on natural nocturnal GH pulse
↓ Apply these values to the reconstitution calculatorTiming: Morning fasted, post-workout, and/or before bed. Space doses 3-4 hours apart; always inject fasted for maximum GH pulse
↓ Apply these values to the reconstitution calculatorTiming: Morning, midday, and bedtime - all fasted. Stack with CJC-1295 no DAC for amplified GH release at each dose
↓ Apply these values to the reconstitution calculatorWeekly Timeline
| Week | Expected Effects |
|---|---|
| Week 1 | Improved sleep depth and quality; mild water retention; subtle increase in recovery speed |
| Week 2 | Enhanced recovery; improved skin hydration; possible reduction in joint discomfort |
| Week 4 | Noticeable body composition changes beginning - modest fat loss and improved muscle fullness |
| Week 8 | Significant body composition improvements; enhanced collagen; better sleep architecture |
| Week 12 | Cumulative GH optimization effects; lean mass preservation; anti-aging skin improvements |
Reconstitution Calculator
1 unit on U-100 syringe = 0.01 mL · Always label your vial after reconstitution
Injection Technique & Reconstitution
- Remove flip-top cap from the peptide vial
- Swab rubber stopper with alcohol swab and allow to dry
- Draw 2 mL bacteriostatic water into syringe
- Slowly inject BAC water down the vial wall - do not spray on powder
- Gently swirl until completely dissolved
- Refrigerate at 2-8C; label with reconstitution date
Use our free mixing calculator to get the exact syringe units for your vial size and dose.
Mechanism of Action
Ipamorelin selectively binds the ghrelin receptor (GHS-R1a) in the pituitary and hypothalamus, stimulating pulsatile growth hormone release from somatotroph cells. It mimics ghrelin's GH-releasing action without significantly elevating cortisol, ACTH, prolactin, or aldosterone - making it the most selective GHRP available. It does not cause significant appetite stimulation unlike GHRP-6. Combined with CJC-1295 to amplify GH pulses via dual GHRH and GHS-R activation.
Key Research Papers
Demonstrated that Ipamorelin stimulates GH release and longitudinal bone growth in rats without affecting cortisol or ACTH levels, establishing its selectivity profile.
View on PubMed →Stacks Well With
The most popular GH optimization stack. CJC-1295 stimulates GHRH receptors while Ipamorelin stimulates GHS-R1a - dual-pathway activation produces significantly amplified GH pulses.
Combines GH secretagogue effects for systemic recovery with BPC-157's local tissue repair and anti-inflammatory actions.
Frequently Asked Questions
Ipamorelin stimulates the pituitary gland to release growth hormone in natural pulses. It is used for anti-aging, body composition improvement, recovery enhancement, and improving sleep quality.
Ipamorelin is highly selective - it stimulates GH without significantly raising cortisol, ACTH, prolactin, or appetite. This makes it safer and more tolerable for long-term use.
Yes - this is the most popular combination. CJC-1295 activates GHRH receptors and Ipamorelin activates GHS-R1a simultaneously, producing synergistic GH pulses significantly greater than either peptide alone.
Legal Status by Region
This information is provided for educational and research purposes only. Not approved for human consumption by the FDA or any regulatory body. Always consult a qualified medical professional.