Selank
Also known as: TP-7 · Selank nasal spray · Threonine-Lysine-Proline-Arg-Pro-Gly-Pro
Selank modulates GABA-A receptor activity, exerting anxiolytic effects comparable to benzodiazepines without dependence or sedation. It enhances serotonergic neurotransmission by increasing serotonin uptake in neurons and upregulates expression of BDNF and enkephalins. It stimulates the release of endogenous opioid peptides...
What It Is
Selank modulates GABA-A receptor activity, exerting anxiolytic effects comparable to benzodiazepines without dependence or sedation. It enhances serotonergic neurotransmission by increasing serotonin uptake in neurons and upregulates expression of BDNF and enkephalins. It stimulates the release of endogenous opioid peptides (Met-enkephalin), contributing to stress reduction and mood stabilization. It also modulates the immune system via Tuftsin-like effects, upregulating IL-2, IL-6, and NK cell activity. The Pro-Gly-Pro tail stabilizes the peptide against enzymatic degradation.
Supplies Needed
Reconstitution solvent
Intranasal delivery device
Sterilization
Storage
Store at -20C for up to 2 years. Protect from light.
Refrigerate at 2-8C; use within 30 days.
This information is provided for educational and research purposes only. Not approved for human consumption by the FDA or any regulatory body. Always consult a qualified medical professional.
Dosing Protocols
Timing: Morning and/or evening. Begin with single dose to assess response; cycle on/off to prevent tolerance
↓ Apply these values to the reconstitution calculatorTiming: Morning and evening. Can be combined with Semax for balanced nootropic effect
↓ Apply these values to the reconstitution calculatorTiming: Morning, noon, and evening. Higher doses for anxiety disorders or severe stress; maintain cycling protocol
↓ Apply these values to the reconstitution calculatorWeekly Timeline
| Week | Expected Effects |
|---|---|
| Week 1 | Reduced anxiety and stress; improved calmness under pressure; slightly improved sleep quality |
| Week 2 | Improved cognitive function under stress; better emotional regulation; reduced stress reactivity |
| Week 4 | Sustained anxiolytic benefit; improved mood stability; enhanced memory under stress conditions |
Reconstitution Calculator
1 unit on U-100 syringe = 0.01 mL · Always label your vial after reconstitution
Injection Technique & Reconstitution
- Remove flip-top cap from the vial
- Swab rubber stopper with alcohol swab
- Draw appropriate volume of sterile saline or bacteriostatic water
- Inject slowly down the vial wall
- Gently swirl until dissolved
- For intranasal use: transfer to nasal spray bottle
- Label with reconstitution date; refrigerate at 2-8C
Use our free peptide calculator to get the exact syringe units for your vial size and dose.
Mechanism of Action
Selank modulates GABA-A receptor activity, exerting anxiolytic effects comparable to benzodiazepines without dependence or sedation. It enhances serotonergic neurotransmission by increasing serotonin uptake in neurons and upregulates expression of BDNF and enkephalins. It stimulates the release of endogenous opioid peptides (Met-enkephalin), contributing to stress reduction and mood stabilization. It also modulates the immune system via Tuftsin-like effects, upregulating IL-2, IL-6, and NK cell activity. The Pro-Gly-Pro tail stabilizes the peptide against enzymatic degradation.
Key Research Papers
Demonstrated anxiolytic and adaptogenic effects of Selank in animal models of stress, with effects comparable to benzodiazepines without sedation or dependence.
View on PubMed →Stacks Well With
Perfect cognitive stack - Semax provides stimulating focus and BDNF while Selank provides anxiolytic effects. Together they optimize cognition without overstimulation or anxiety.
Selank reduces daytime anxiety while DSIP improves sleep quality at night - a comprehensive stress management and sleep optimization stack.
Frequently Asked Questions
Selank is a synthetic anxiolytic and nootropic peptide used for reducing anxiety, improving cognitive function under stress, and mood stabilization. It works similarly to benzodiazepines but without dependence or sedation.
No - unlike benzodiazepines, Selank does not cause physical dependence or withdrawal symptoms. It modulates GABA-A receptors without the tolerance-forming mechanisms of benzodiazepines.
Yes - this is a popular combination. Semax provides stimulating focus and BDNF upregulation while Selank provides anxiety reduction. Together they produce a balanced, calm focus without overstimulation.
Legal Status by Region
This information is provided for educational and research purposes only. Not approved for human consumption by the FDA or any regulatory body. Always consult a qualified medical professional.